Isaiah Haastrup, a baby at the centre of a legal row over his treatment, has died, his parents have confirmed.
An appeal by the parents of the 12-month-old to continue his life-support treatment was dismissed by European judges on Tuesday.
Isaiah suffered “catastrophic” brain damage due to being deprived of oxygen at birth.
His parents fought a lengthy legal battle with King’s College Hospital to allow further care for their son.
Isaiah’s father said he was “so proud” of his “brave” son as he died at 19:50 GMT on Wednesday – hours after his life-support was withdrawn.
Talking to the BBC, Isaiah’s mother Takesha Thomas said her son had “a little cheekiness about him, which I will miss.”
“But right now all I can feel is just pure anger. All I know is justice wasn’t served – at all.”
Ms Thomas and Lanre Haastrup had asked the European Court of Human Rights (ECHR) to intervene after losing two court battles in the UK, but the case was again dismissed by judges.
An ECHR spokesman said the application had been declared “inadmissible”.
Doctors said Isaiah was in a low level of consciousness, could not move or breathe independently and was connected to a ventilator.
King’s College Hospital in London said providing further intensive care treatment was not in his best interests.
A spokesman for the hospital said: “The trust always provided Isaiah with the very best care, and the decision to apply to the courts to withdraw treatment was only made after careful consideration and after consultation with the family.
“We recognise that this has been an extremely difficult time for Isaiah’s family as well as those involved in his care since birth.”